Error 2318 ::The remote server returned an error: (404) Not Found. Biology Job Durham North Carolina | Associate Scientist / Scientist - Cell Biology United Therapeutics Corporation

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Associate Scientist / Scientist - Cell Biology

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United Therapeutics Corporation
Health Care, Other
Durham
North Carolina
click here to apply

Associate Scientist / Scientist - Cell Biology Job Description

The Job Details are as follows:



Position Overview:

Develop scalable cell culture and exosome purification processes to improve production of regenerative medicine products.


Key Accountabilities / Responsibilities:

  • Lead efforts in upstream bioprocess development, with particular focus on the efficient expansion of adherent and non-adherent cells (e.g. stem cells, adult primary cells) in cell culture bioreactors
  • Conduct insightful studies to improve the yield (biogenesis) and/or potency of therapeutically-relevant exosomes
  • Fully interrogate cell signaling pathways to understand the effects of cell culture conditions on mechanistic attributes
  • Implement cell culture and purification strategies to ‘customize’ exosome products for targeted clinical indications
  • Lead cell line development activities for the purpose of producing therapeutically-relevant exosomes
  • Lead technical development activities for next-generation exosome products
  • Support efforts in downstream bioprocess development, focusing on methods for cell harvest from bioreactors and isolation of exosomes from cell culture supernatant
  • Support efforts to identify chromatographic (affinity, ion-exchange) methods for the purification of exosomes, with a focus on scalable manufacturing methods
  • Complete bioprocess workflows for exosome-based products. Identify process gaps, and develop in-process and end-of-process analytical methods for evaluating product quality
  • Participate in tech transfer of methods to external research or manufacturing organizations as needed
  • Author, review, and/or approve protocols for the production of cell and cell-based materials
  • Author and/or review scientific manuscripts and regulatory submissions
  • Regularly present and discuss data with laboratory staff, program leaders, and senior management as needed
  • Manage external relationships (CRO, CMO, academic, industry, government) pertaining to product R&D
  • Indirectly manage small teams (2-4 staff members) for product development, including proof-of-concept experiments, scale-up studies, and production runs
  • Frequent interactions with laboratory personnel and program leaders in Regenerative Medicine.  Additional interactions with Facilities, Regulatory, Quality and other internal departments on an as-needed basis

Minimum Requirements:

  • PhD in Cell/Molecular Biology, Biomedical Engineering, Biomanufacturing or related field with 2-5 years of relevant academic or post-graduate experience.
  • Master’s or Bachelor’s Degree in Cell/Molecular Biology, Biotechnology, Biomedical Engineering, Biomanufacturing or related field with 5-10 years of relevant experience
  • 1-5 years of industry or academic experience in the development of biologics (cells, or cell-derived products) for therapeutic use
  • 1-5 years of experience with operating cell culture bioreactors and/or chromatography systems
  • Stem or progenitor cell culture, flow cytometry, and molecular biology experience a plus


Preferred Knowledge, Skills, and Abilities:

  • Stem or progenitor cell culture, flow cytometry, and molecular biology experience a plus
  • Excellent organizational skills with great attention to detail and quality of work
  • Ability to problem-solve in a creative and effective manner
  • Good team member skills; must work well with others
  • Good written and oral communication skills
  • Ability to initiate and manage day-to-day tasks effectively, including multi-tasking, flexibility and adaptability
  • Ability to organize and present data
  • Ability to independently follow experimental methods and protocols
  • Highly self-motivated

United Therapeutics  Corporation is an Equal Opportunity/Affirmative Action Employer - EOE Minorities / Females / Protected Veterans / Individuals with Disabilities


Durham Biology Job

Associate Scientist / Scientist - Cell Biology Job Requirements

 
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